Deletion of SUMO1 attenuates behavioral and anatomical deficits by regulating autophagic activities in Huntington disease

The CAG expansion of huntingtin (mHTT) associated with Huntington disease (HD) is a ubiquitously expressed gene, yet it prominently damages the striatum and cortex, followed by widespread peripheral defects as the disease progresses. However, the underlying mechanisms of neuronal vulnerability are u...

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Detalles Bibliográficos
Autores principales: Ramírez-Jarquín, Uri Nimrod, Sharma, Manish, Zhou, Wuyue, Shahani, Neelam, Subramaniam, Srinivasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812691/
https://www.ncbi.nlm.nih.gov/pubmed/35086928
http://dx.doi.org/10.1073/pnas.2107187119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812691/
https://www.ncbi.nlm.nih.gov/pubmed/35086928
http://dx.doi.org/10.1073/pnas.2107187119

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