Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus

EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral activity. In this study, we surprisingly found...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Danwei, Zhu, Yuanmei, Yan, Hongxia, Wu, Tong, Chong, Huihui, He, Yuxian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812798/
https://www.ncbi.nlm.nih.gov/pubmed/33847245
http://dx.doi.org/10.1080/22221751.2021.1917309

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812798/
https://www.ncbi.nlm.nih.gov/pubmed/33847245
http://dx.doi.org/10.1080/22221751.2021.1917309

Ejemplares similares