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Pan-coronavirus fusion inhibitors possess potent inhibitory activity against HIV-1, HIV-2, and simian immunodeficiency virus

EK1 peptide is a membrane fusion inhibitor with broad-spectrum activity against human coronaviruses (CoVs). In the outbreak of COVID-19, we generated a lipopeptide EK1V1 by modifying EK1 with cholesterol, which exhibited significantly improved antiviral activity. In this study, we surprisingly found...

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Detalles Bibliográficos
Autores principales:	Yu, Danwei, Zhu, Yuanmei, Yan, Hongxia, Wu, Tong, Chong, Huihui, He, Yuxian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812798/ https://www.ncbi.nlm.nih.gov/pubmed/33847245 http://dx.doi.org/10.1080/22221751.2021.1917309

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