Cargando…

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

Modestly increased expression of transactive response DNA binding protein (TDP-43) gene have been reported in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neuromuscular diseases. However, whether this modest elevation triggers neurodegeneration is not known. Although...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Chunxing, Qiao, Tao, Yu, Jia, Wang, Hongyan, Guo, Yansu, Salameh, Johnny, Metterville, Jake, Parsi, Sepideh, Yusuf, Issa, Brown, Robert H., Cai, Huaibin, Xu, Zuoshang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812852/
https://www.ncbi.nlm.nih.gov/pubmed/35113871
http://dx.doi.org/10.1371/journal.pone.0255710