Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

Modestly increased expression of transactive response DNA binding protein (TDP-43) gene have been reported in amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD), and other neuromuscular diseases. However, whether this modest elevation triggers neurodegeneration is not known. Although...

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Detalles Bibliográficos
Autores principales: Yang, Chunxing, Qiao, Tao, Yu, Jia, Wang, Hongyan, Guo, Yansu, Salameh, Johnny, Metterville, Jake, Parsi, Sepideh, Yusuf, Issa, Brown, Robert H., Cai, Huaibin, Xu, Zuoshang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812852/
https://www.ncbi.nlm.nih.gov/pubmed/35113871
http://dx.doi.org/10.1371/journal.pone.0255710

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