Reduced blood pressure in sickle cell disease is associated with decreased angiotensin converting enzyme (ACE) activity and is not modulated by ACE inhibition

BACKGROUND: Sickle cell disease (SCD) incurs vaso-occlusive episodes and organ damage, including nephropathy. Despite displaying characteristics of vascular dysfunction, SCD patients tend to present relatively lower systemic blood pressure (BP), via an unknown mechanism. We investigated associations...

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Detalles Bibliográficos
Autores principales: Brito, Pamela L., dos Santos, Alisson F., Chweih, Hanan, Favero, Maria E., Gotardo, Erica M. F., Silva, Juliete A. F., Leonardo, Flavia C., Franco-Penteado, Carla F., de Oliveira, Mariana G., Ferreira, Wilson A., Zaidan, Bruna C., Billis, Athanase, Baldanzi, Giorgio, Mashima, Denise A., Antunes, Edson, Saad, Sara T. Olalla, Costa, Fernando F., Conran, Nicola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812860/
https://www.ncbi.nlm.nih.gov/pubmed/35113975
http://dx.doi.org/10.1371/journal.pone.0263424

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812860/
https://www.ncbi.nlm.nih.gov/pubmed/35113975
http://dx.doi.org/10.1371/journal.pone.0263424

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