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Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality

The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether ORAI1 itself is associated with an increased ris...

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Detalles Bibliográficos
Autores principales: Shawer, Heba, Cheng, Chew W., Bailey, Marc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812896/
https://www.ncbi.nlm.nih.gov/pubmed/35113933
http://dx.doi.org/10.1371/journal.pone.0263303
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author Shawer, Heba
Cheng, Chew W.
Bailey, Marc A.
author_facet Shawer, Heba
Cheng, Chew W.
Bailey, Marc A.
author_sort Shawer, Heba
collection PubMed
description The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether ORAI1 itself is associated with an increased risk for severe COVID-19 presentation is still unknown. Here, we employed genetic association analysis to investigate the potential association of host genetic polymorphisms of ORAI1 with the risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and its associated COVID-19 fatality in UK Biobank participants from white British background. The analysis showed no significant association between ORAI1 variants and COVID-19 positivity or fatality, despite the well-established roles of ORAI1 in immune response and inflammation and the success of ORAI1 inhibition in clinical trials. Our results suggest that the host genetic polymorphisms of ORAI1 are unlikely to be implicated in the broad variability in symptoms severity among afflicted patients.
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spelling pubmed-88128962022-02-04 Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality Shawer, Heba Cheng, Chew W. Bailey, Marc A. PLoS One Research Article The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Whether ORAI1 itself is associated with an increased risk for severe COVID-19 presentation is still unknown. Here, we employed genetic association analysis to investigate the potential association of host genetic polymorphisms of ORAI1 with the risk of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection and its associated COVID-19 fatality in UK Biobank participants from white British background. The analysis showed no significant association between ORAI1 variants and COVID-19 positivity or fatality, despite the well-established roles of ORAI1 in immune response and inflammation and the success of ORAI1 inhibition in clinical trials. Our results suggest that the host genetic polymorphisms of ORAI1 are unlikely to be implicated in the broad variability in symptoms severity among afflicted patients. Public Library of Science 2022-02-03 /pmc/articles/PMC8812896/ /pubmed/35113933 http://dx.doi.org/10.1371/journal.pone.0263303 Text en © 2022 Shawer et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shawer, Heba
Cheng, Chew W.
Bailey, Marc A.
Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality
title Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality
title_full Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality
title_fullStr Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality
title_full_unstemmed Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality
title_short Absence of association between host genetic mutations in the ORAI1 gene and COVID-19 fatality
title_sort absence of association between host genetic mutations in the orai1 gene and covid-19 fatality
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812896/
https://www.ncbi.nlm.nih.gov/pubmed/35113933
http://dx.doi.org/10.1371/journal.pone.0263303
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