Base-resolution models of transcription factor binding reveal soft motif syntax

The arrangement of transcription factor (TF) binding motifs (syntax) is an important part of the cis-regulatory code, yet remains elusive. We introduce a deep learning model, BPNet, that uses DNA sequence to predict base-resolution ChIP-nexus binding profiles of pluripotency TFs. We develop interpre...

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Detalles Bibliográficos
Autores principales: Avsec, Žiga, Weilert, Melanie, Shrikumar, Avanti, Krueger, Sabrina, Alexandari, Amr, Dalal, Khyati, Fropf, Robin, McAnany, Charles, Gagneur, Julien, Kundaje, Anshul, Zeitlinger, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812996/
https://www.ncbi.nlm.nih.gov/pubmed/33603233
http://dx.doi.org/10.1038/s41588-021-00782-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8812996/
https://www.ncbi.nlm.nih.gov/pubmed/33603233
http://dx.doi.org/10.1038/s41588-021-00782-6

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