Alu RNA Structural Features Modulate Immune Cell Activation and A-to-I Editing of Alu RNAs Is Diminished in Human Inflammatory Bowel Disease

Alu retrotransposons belong to the class of short interspersed nuclear elements (SINEs). Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with significant pathological consequences. Mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales: Aune, Thomas M., Tossberg, John T., Heinrich, Rachel M., Porter, Krislyn P., Crooke, Philip S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813004/
https://www.ncbi.nlm.nih.gov/pubmed/35126398
http://dx.doi.org/10.3389/fimmu.2022.818023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813004/
https://www.ncbi.nlm.nih.gov/pubmed/35126398
http://dx.doi.org/10.3389/fimmu.2022.818023

Ejemplares similares