Population Pharmacokinetics of Tadalafil in Pediatric Patients with Pulmonary Arterial Hypertension: A Combined Adult/Pediatric Model

BACKGROUND: Tadalafil 40 mg once daily is approved for adult patients with pulmonary arterial hypertension (PAH). To investigate and potentially fulfill an unmet need in pediatric patients with PAH, pharmacokinetic (PK) data were explored in a pediatric phase Ib/II study and pooled with prior phase...

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Detalles Bibliográficos
Autores principales: Ferguson-Sells, Lisa, Velez de Mendizabal, Nieves, Li, Baohui, Small, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813705/
https://www.ncbi.nlm.nih.gov/pubmed/34379314
http://dx.doi.org/10.1007/s40262-021-01052-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813705/
https://www.ncbi.nlm.nih.gov/pubmed/34379314
http://dx.doi.org/10.1007/s40262-021-01052-8

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