Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption

BACKGROUND AND OBJECTIVES: Physiologically based pharmacokinetic (PBPK) modelling has evolved to accommodate different routes of drug administration and enables prediction of drug concentrations in tissues as well as plasma. The inhalation route of administration has proven successful in treating re...

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Detalles Bibliográficos
Autores principales: Miller, Neil A., Graves, Rebecca H., Edwards, Chris D., Amour, Augustin, Taylor, Ed, Robb, Olivia, O’Brien, Brett, Patel, Aarti, Harrell, Andrew W., Hessel, Edith M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813803/
https://www.ncbi.nlm.nih.gov/pubmed/34458976
http://dx.doi.org/10.1007/s40262-021-01066-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813803/
https://www.ncbi.nlm.nih.gov/pubmed/34458976
http://dx.doi.org/10.1007/s40262-021-01066-2

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