Cargando…

cFLIP downregulation is an early event required for endoplasmic reticulum stress-induced apoptosis in tumor cells

Protein misfolding or unfolding and the resulting endoplasmic reticulum (ER) stress frequently occur in highly proliferative tumors. How tumor cells escape cell death by apoptosis after chronic ER stress remains poorly understood. We have investigated in both two-dimensional (2D) cultures and multic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mora-Molina, Rocío, Stöhr, Daniela, Rehm, Markus, López-Rivas, Abelardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813907/ https://www.ncbi.nlm.nih.gov/pubmed/35115486 http://dx.doi.org/10.1038/s41419-022-04574-6

Ejemplares similares

FLIP the Switch: Regulation of Apoptosis and Necroptosis by cFLIP
por: Tsuchiya, Yuichi, et al.
Publicado: (2015)

Restoring TRAILR2/DR5-Mediated Activation of Apoptosis upon Endoplasmic Reticulum Stress as a Therapeutic Strategy in Cancer
por: Mora-Molina, Rocío, et al.
Publicado: (2022)

YM155 sensitizes HeLa cells to TRAIL-mediated apoptosis via cFLIP and survivin downregulation
por: Chandrasekaran, Arun Pandian, et al.
Publicado: (2020)

MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis
por: Suk, Fat-Moon, et al.
Publicado: (2021)

cFLIP expression is altered in severe corticosteroid-resistant asthma
por: Lazarev, Dennis, et al.
Publicado: (2014)

cFLIP overexpression in T cells in thymoma-associated myasthenia gravis
por: Belharazem, Djeda, et al.
Publicado: (2015)

Computational modelling of LY303511 and TRAIL-induced apoptosis suggests dynamic regulation of cFLIP
por: Shi, Yuan, et al.
Publicado: (2013)

Maritoclax Enhances TRAIL-Induced Apoptosis via CHOP-Mediated Upregulation of DR5 and miR-708-Mediated Downregulation of cFLIP
por: Jeon, Mi-Yeon, et al.
Publicado: (2018)

TNF Is Partially Required for Cell-Death-Triggered Skin Inflammation upon Acute Loss of cFLIP
por: Feoktistova, Maria, et al.
Publicado: (2020)

Identification and Characterization of the Interaction Site between cFLIP(L) and Calmodulin
por: Gaidos, Gabriel, et al.
Publicado: (2015)

Regulation of the antiapoptotic protein cFLIP by the glucocorticoid Dexamethasone in ALL cells
por: Kleinesudeik, Lara, et al.
Publicado: (2018)

cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition
por: Padmanabhan, Chandrasekhar, et al.
Publicado: (2017)

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation
por: Henrich, C J, et al.
Publicado: (2015)

FADD regulates NF-κB activation and promotes ubiquitination of cFLIP(L) to induce apoptosis
por: Ranjan, Kishu, et al.
Publicado: (2016)

Induction of Breast Cancer Cell Apoptosis by TRAIL and Smac Mimetics: Involvement of RIP1 and cFLIP
por: Holmgren, Christian, et al.
Publicado: (2022)

Inhibition of Methyltransferases Accelerates Degradation of cFLIP and Sensitizes B-Cell Lymphoma Cells to TRAIL-Induced Apoptosis
por: Braun, Frank K., et al.
Publicado: (2015)

Icariside II overcomes TRAIL resistance of melanoma cells through ROS-mediated downregulation of STAT3/cFLIP signaling
por: Du, Juan, et al.
Publicado: (2016)

Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP
por: Hirpara, Jayshree L., et al.
Publicado: (2019)

Kurarinone promotes TRAIL-induced apoptosis by inhibiting NF-κB-dependent cFLIP expression in HeLa cells
por: Seo, Ok-Won, et al.
Publicado: (2012)

MIND bomb 2 prevents RIPK1 kinase activity-dependent and -independent apoptosis through ubiquitylation of cFLIP(L)
por: Nakabayashi, Osamu, et al.
Publicado: (2021)

The deubiquitinase Usp27x as a novel regulator of cFLIP(L) protein expression and sensitizer to death-receptor-induced apoptosis
por: Dold, Manuel Nico, et al.
Publicado: (2022)

Ca(2+) influx-mediated dilation of the endoplasmic reticulum and c-FLIP(L) downregulation trigger CDDO-Me–induced apoptosis in breast cancer cells
por: Jeong, Soo Ah, et al.
Publicado: (2015)

Emodin Suppresses Hyperglycemia-Induced Proliferation and Fibronectin Expression in Mesangial Cells via Inhibiting cFLIP
por: Gao, Junjie, et al.
Publicado: (2014)

Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1
por: Lemke, J, et al.
Publicado: (2014)

Independent Induction of Caspase-8 and cFLIP Expression during Colorectal Carcinogenesis in Sporadic and HNPCC Adenomas and Carcinomas
por: Heijink, D. M., et al.
Publicado: (2007)

Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling
por: Belharazem, Djeda, et al.
Publicado: (2017)

Cleavage of cFLIP restrains cell death during viral infection and tissue injury and favors tissue repair
por: Martinez Lagunas, Kristel, et al.
Publicado: (2023)

Endoplasmic reticulum stress and apoptosis
por: Faitova, Jitka, et al.
Publicado: (2006)

Expressions of IGFBP-5, cFLIP in cervical intraepithelial neoplasia, cervical carcinoma and their clinical significances: a molecular pathology
por: Hou, Xue-Jing, et al.
Publicado: (2009)

Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL
por: French, Rhiannon, et al.
Publicado: (2015)

Panbinostat decreases cFLIP and enhances killing of cancer cells by immunotoxin LMB-100 by stimulating the extrinsic apoptotic pathway
por: Liu, Xiu-Fen, et al.
Publicado: (2017)

Cellular FLICE-like inhibitory protein (cFLIP) critically maintains apoptotic resistance in human lens epithelial cells
por: Huangfu, Jingru, et al.
Publicado: (2021)

Embelin downregulated cFLIP in breast cancer cell lines facilitate anti-tumor effect of IL-1β-stimulated human umbilical cord mesenchymal stem cells
por: Liang, Ya-Han, et al.
Publicado: (2021)

Oncogenic p95HER2/611CTF primes human breast epithelial cells for metabolic stress-induced down-regulation of FLIP and activation of TRAIL-R/Caspase-8-dependent apoptosis
por: Martín-Pérez, Rosa, et al.
Publicado: (2017)

Sensitization of glycoengineered interferon-β1a-resistant cancer cells by cFLIP inhibition for enhanced anti-cancer therapy
por: Kim, Tae-Eun, et al.
Publicado: (2017)

Involvement of both caspase-8 and Noxa-activated pathways in endoplasmic reticulum stress-induced apoptosis in triple-negative breast tumor cells
por: Cano-González, Ana, et al.
Publicado: (2018)

Requirement of biphasic calcium release from the endoplasmic reticulum for Fas-mediated apoptosis
por: Wozniak, Ann L., et al.
Publicado: (2006)

Optineurin downregulation induces endoplasmic reticulum stress, chaperone-mediated autophagy, and apoptosis in pancreatic cancer cells
por: Ali, Doaa M., et al.
Publicado: (2019)

Endoplasmic Reticulum Stress-Mediated p62 Downregulation Inhibits Apoptosis via c-Jun Upregulation
por: Yu, Wenjun, et al.
Publicado: (2021)

Conformational Requirements for Glycoprotein Reglucosylation in the Endoplasmic Reticulum
por: Trombetta, E. Sergio, et al.
Publicado: (2000)

Cannot write session to /tmp/vufind_sessions/sess_aj5kb7l8asqb6ql62tba1dgfnj