Genetically stable CRISPR-based kill switches for engineered microbes

Microbial biocontainment is an essential goal for engineering safe, next-generation living therapeutics. However, the genetic stability of biocontainment circuits, including kill switches, is a challenge that must be addressed. Kill switches are among the most difficult circuits to maintain due to t...

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Detalles Bibliográficos
Autores principales: Rottinghaus, Austin G., Ferreiro, Aura, Fishbein, Skye R. S., Dantas, Gautam, Moon, Tae Seok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813983/
https://www.ncbi.nlm.nih.gov/pubmed/35115506
http://dx.doi.org/10.1038/s41467-022-28163-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813983/
https://www.ncbi.nlm.nih.gov/pubmed/35115506
http://dx.doi.org/10.1038/s41467-022-28163-5

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