WIN site inhibition disrupts a subset of WDR5 function

WDR5 nucleates the assembly of histone-modifying complexes and acts outside this context in a range of chromatin-centric processes. WDR5 is also a prominent target for pharmacological inhibition in cancer. Small-molecule degraders of WDR5 have been described, but most drug discovery efforts center o...

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Detalles Bibliográficos
Autores principales: Siladi, Andrew J., Wang, Jing, Florian, Andrea C., Thomas, Lance R., Creighton, Joy H., Matlock, Brittany K., Flaherty, David K., Lorey, Shelly L., Howard, Gregory C., Fesik, Stephen W., Weissmiller, April M., Liu, Qi, Tansey, William P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813994/
https://www.ncbi.nlm.nih.gov/pubmed/35115608
http://dx.doi.org/10.1038/s41598-022-05947-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813994/
https://www.ncbi.nlm.nih.gov/pubmed/35115608
http://dx.doi.org/10.1038/s41598-022-05947-9

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