DGKZ promotes TGFβ signaling pathway and metastasis in triple-negative breast cancer by suppressing lipid raft-dependent endocytosis of TGFβR2

Diacylglycerol kinase ζ (DGKZ) is a diacylglycerol kinase that metabolizes diacylglycerol to yield phosphatidic acid, and its function in breast cancer progression remains unclear. In this study, via screening of a CRISPR-Cas9 knockout library containing lipid metabolic genes, DGKZ was identified as...

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Detalles Bibliográficos
Autores principales: Zhao, Yuanyuan, Sun, Hefen, Li, Xuan, Liu, Qiqi, Liu, Yang, Hou, Yifeng, Jin, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814002/
https://www.ncbi.nlm.nih.gov/pubmed/35115500
http://dx.doi.org/10.1038/s41419-022-04537-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814002/
https://www.ncbi.nlm.nih.gov/pubmed/35115500
http://dx.doi.org/10.1038/s41419-022-04537-x

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