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Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis
Sustained mitochondrial fitness relies on coordinated biogenesis and clearance. Both processes are regulated by constant targeting of proteins into the organelle. Thus, mitochondrial protein import sets the pace for mitochondrial abundance and function. However, our understanding of mitochondrial pr...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814026/ https://www.ncbi.nlm.nih.gov/pubmed/35115503 http://dx.doi.org/10.1038/s41467-022-28272-1 |