Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks

Identifying the molecular systems and proteins that modify the progression of Alzheimer’s disease and related dementias (ADRD) is central to drug target selection. However, discordance between mRNA and protein abundance, and the scarcity of proteomic data, has limited our ability to advance candidat...

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Detalles Bibliográficos
Autores principales: Tasaki, Shinya, Xu, Jishu, Avey, Denis R., Johnson, Lynnaun, Petyuk, Vladislav A., Dawe, Robert J., Bennett, David A., Wang, Yanling, Gaiteri, Chris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814036/
https://www.ncbi.nlm.nih.gov/pubmed/35115553
http://dx.doi.org/10.1038/s41467-022-28280-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814036/
https://www.ncbi.nlm.nih.gov/pubmed/35115553
http://dx.doi.org/10.1038/s41467-022-28280-1

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