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Inferring protein expression changes from mRNA in Alzheimer’s dementia using deep neural networks
Identifying the molecular systems and proteins that modify the progression of Alzheimer’s disease and related dementias (ADRD) is central to drug target selection. However, discordance between mRNA and protein abundance, and the scarcity of proteomic data, has limited our ability to advance candidat...
Autores principales: | Tasaki, Shinya, Xu, Jishu, Avey, Denis R., Johnson, Lynnaun, Petyuk, Vladislav A., Dawe, Robert J., Bennett, David A., Wang, Yanling, Gaiteri, Chris |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814036/ https://www.ncbi.nlm.nih.gov/pubmed/35115553 http://dx.doi.org/10.1038/s41467-022-28280-1 |
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