Identification and selection of healthy spermatozoa in heterozygous carriers of the Phe508del-variant of the CFTR-gene in assisted reproduction

The pathogenic variant Phe508del of the CFTR-gene is the most frequent cause of cystic fibrosis (CF). Whereas male CF-patients are infertile due to bilateral agenesis of the efferent ducts, the fertility status of male heterozygous carriers is uncertain. We aimed at demonstrating the involvement of...

Descripción completa

Detalles Bibliográficos
Autores principales: De Geyter, Julie, Gallati-Kraemer, Sabina, Zhang, Hong, De Geyter, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814069/
https://www.ncbi.nlm.nih.gov/pubmed/35115637
http://dx.doi.org/10.1038/s41598-022-05925-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814069/
https://www.ncbi.nlm.nih.gov/pubmed/35115637
http://dx.doi.org/10.1038/s41598-022-05925-1

Ejemplares similares