Gαi2-induced conductin/axin2 condensates inhibit Wnt/β-catenin signaling and suppress cancer growth

Conductin/axin2 is a scaffold protein negatively regulating the pro-proliferative Wnt/β-catenin signaling pathway. Accumulation of scaffold proteins in condensates frequently increases their activity, but whether condensation contributes to Wnt pathway inhibition by conductin remains unclear. Here,...

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Detalles Bibliográficos
Autores principales: Miete, Cezanne, Solis, Gonzalo P., Koval, Alexey, Brückner, Martina, Katanaev, Vladimir L., Behrens, Jürgen, Bernkopf, Dominic B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814139/
https://www.ncbi.nlm.nih.gov/pubmed/35115535
http://dx.doi.org/10.1038/s41467-022-28286-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814139/
https://www.ncbi.nlm.nih.gov/pubmed/35115535
http://dx.doi.org/10.1038/s41467-022-28286-9

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