A disease-linked lncRNA mutation in RNase MRP inhibits ribosome synthesis

RMRP encodes a non-coding RNA forming the core of the RNase MRP ribonucleoprotein complex. Mutations cause Cartilage Hair Hypoplasia (CHH), characterized by skeletal abnormalities and impaired T cell activation. Yeast RNase MRP cleaves a specific site in the pre-ribosomal RNA (pre-rRNA) during ribos...

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Detalles Bibliográficos
Autores principales: Robertson, Nic, Shchepachev, Vadim, Wright, David, Turowski, Tomasz W., Spanos, Christos, Helwak, Aleksandra, Zamoyska, Rose, Tollervey, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814244/
https://www.ncbi.nlm.nih.gov/pubmed/35115551
http://dx.doi.org/10.1038/s41467-022-28295-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814244/
https://www.ncbi.nlm.nih.gov/pubmed/35115551
http://dx.doi.org/10.1038/s41467-022-28295-8

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