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Correspondence Between Genomic- and Genealogical/Coalescent-Based Inference of Homozygosity by Descent in Large French-Canadian Genealogies

Research on the genetics of complex traits overwhelmingly focuses on the additive effects of genes. Yet, animal studies have shown that non-additive effects, in particular homozygosity effects, can shape complex traits. Recent investigations in human studies found some significant homozygosity effec...

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Detalles Bibliográficos
Autores principales: Burkett, Kelly M., Rakesh, Mohan, Morris, Patricia, Vézina, Hélène, Laprise, Catherine, Freeman, Ellen E., Roy-Gagnon, Marie-Hélène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814340/
https://www.ncbi.nlm.nih.gov/pubmed/35126470
http://dx.doi.org/10.3389/fgene.2021.808829