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Prediction of Residue-specific Contributions to Binding and Thermal Stability Using Yeast Surface Display

Accurate prediction of residue burial as well as quantitative prediction of residue-specific contributions to protein stability and activity is challenging, especially in the absence of experimental structural information. This is important for prediction and understanding of disease causing mutatio...

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Detalles Bibliográficos
Autores principales: Ahmed, Shahbaz, Bhasin, Munmun, Manjunath, Kavyashree, Varadarajan, Raghavan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814602/
https://www.ncbi.nlm.nih.gov/pubmed/35127820
http://dx.doi.org/10.3389/fmolb.2021.800819