Structural insights into the specific interaction between Geobacillus stearothermophilus tryptophanyl-tRNA synthetase and antimicrobial Chuangxinmycin

The potential antimicrobial compound Chuangxinmycin (CXM) targets the tryptophanyl-tRNA synthetase (TrpRS) of both Gram-negative and Gram-positive bacteria. However, the specific steric recognition mode and interaction mechanism between CXM and TrpRS is unclear. Here, we studied this interaction usi...

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Detalles Bibliográficos
Autores principales: Fan, Shuai, Lv, Guangxin, Feng, Xiao, Wu, Guangteng, Jin, Yuanyuan, Yan, Maocai, Yang, Zhaoyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814664/
https://www.ncbi.nlm.nih.gov/pubmed/35031320
http://dx.doi.org/10.1016/j.jbc.2022.101580

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814664/
https://www.ncbi.nlm.nih.gov/pubmed/35031320
http://dx.doi.org/10.1016/j.jbc.2022.101580

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