The GSK3 kinase and LZTR1 protein regulate the stability of Ras family proteins and the proliferation of pancreatic cancer cells

Ras family proteins are membrane-bound GTPases that control proliferation, survival, and motility. Many forms of cancers are driven by the acquisition of somatic mutations in a RAS gene. In pancreatic cancer (PC), more than 90% of tumors carry an activating mutation in KRAS. Mutations in components...

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Detalles Bibliográficos
Autores principales: Palanivel, Chitra, Chaudhary, Neha, Seshacharyulu, Parthasarathy, Cox, Jesse L., Yan, Ying, Batra, Surinder K., Ouellette, Michel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2022
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814762/
https://www.ncbi.nlm.nih.gov/pubmed/35114566
http://dx.doi.org/10.1016/j.neo.2022.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8814762/
https://www.ncbi.nlm.nih.gov/pubmed/35114566
http://dx.doi.org/10.1016/j.neo.2022.01.002

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