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Multiple distinct domains of human XIST are required to coordinate gene silencing and subsequent heterochromatin formation
BACKGROUND: Mammalian dosage compensation is achieved by the inactivation of one X chromosome in XX individuals. In eutheria this process is initiated early in development by the long non-coding RNA XIST. Studies of the initiation of silencing by XIST have focussed on mouse models, so the domains of...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815261/ https://www.ncbi.nlm.nih.gov/pubmed/35120578 http://dx.doi.org/10.1186/s13072-022-00438-7 |