Cargando…

Single Impact Injury of Vertebral Endplates Without Structural Disruption, Initiates Disc Degeneration Through Piezo1 Mediated Inflammation and Metabolism Dysfunction

In vitro experimental study. OBJECTIVE. To establish an axial impact injury model of intervertebral disc (IVD) and to investigate if a single impact injury without endplate structural disruption could initiate intervertebral disc degeneration (IDD), and what is the roles of Piezo1 in this process. S...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Zhengang, Zheng, Xinfeng, Li, Songbo, Zeng, Baozhu, Yang, Jiaming, Ling, Zemin, Liu, Xizhe, Wei, Fuxin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2022
Materias:	Basic Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8815838/ https://www.ncbi.nlm.nih.gov/pubmed/34431832 http://dx.doi.org/10.1097/BRS.0000000000004203

Ejemplares similares

Analysis of Correlation Between Vertebral Endplate Change and Lumbar Disc Degeneration
por: Xiao, Long, et al.
Publicado: (2017)

Elimination of Senescent Cells by Senolytics Facilitates Bony Endplate Microvessel Formation and Mitigates Disc Degeneration in Aged Mice
por: Chen, Bolin, et al.
Publicado: (2022)

The role of endplate injury in intervertebral disc degeneration after vertebral augmentation in OVCF patients
por: Li, Yongchao, et al.
Publicado: (2023)

Significance of Vertebral Endplate Failure in Symptomatic Lumbar Disc Herniation
por: Sahoo, Madan Mohan, et al.
Publicado: (2017)

Cationic Polymer Brush-Modified Carbon Nanotube-Meditated eRNA LINC02569 Silencing Attenuates Nucleus Pulposus Degeneration by Blocking NF-κB Signaling Pathway and Alleviate Cell Senescence
por: Huang, Yulin, et al.
Publicado: (2022)

Single-Cell RNA-Seq Analysis Reveals Macrophage Involved in the Progression of Human Intervertebral Disc Degeneration
por: Ling, Zemin, et al.
Publicado: (2022)

The Endplate Role in Degenerative Disc Disease Research: The Isolation of Human Chondrocytes from Vertebral Endplate—An Optimised Protocol
por: Gradišnik, Lidija, et al.
Publicado: (2022)

Comparison of the Extent of Degeneration among the Normal Disc, Immobilized Disc, and Immobilized Disc with an Endplate Fracture
por: Choi, Wonki, et al.
Publicado: (2017)

Image classification of osteoporotic vertebral fracture with endplate-disc complex Injury
por: Zhang, Shuai, et al.
Publicado: (2021)

Vertebral Endplate Changes Correlate with Presence of Cartilaginous Endplate in the Herniated Disc Tissue: Factor Predicting Failure of Conservative Treatment
por: Latif, Rabia, et al.
Publicado: (2022)

MRI signal changes and their association with intervertebral disc disease in canine vertebral endplates
por: Deards, Emma, et al.
Publicado: (2019)

Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats
por: Sun, Qi, et al.
Publicado: (2021)

The contributions of cartilage endplate composition and vertebral bone marrow fat to intervertebral disc degeneration in patients with chronic low back pain
por: Bonnheim, Noah B., et al.
Publicado: (2022)

Correction to: Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats
por: Sun, Qi, et al.
Publicado: (2021)

The impact of dyslipidemia on lumbar intervertebral disc degeneration and vertebral endplate modic changes: a cross-sectional study of 1035 citizens in China
por: Yuan, Liang, et al.
Publicado: (2023)

Relationship Between Endplate Defects, Modic Change, Facet Joint Degeneration, and Disc Degeneration of Cervical Spine
por: Lee, Su-Hun, et al.
Publicado: (2020)

Characteristics of Stem Cells Derived from the Degenerated Human Intervertebral Disc Cartilage Endplate
por: Liu, Lan-Tao, et al.
Publicado: (2011)

The correlation between microvessel pathological changes of the endplate and degeneration of the intervertebral disc in diabetic rats
por: CHEN, SEN, et al.
Publicado: (2013)

Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice
por: Xiao, Zhi-feng, et al.
Publicado: (2018)

The correlation between microvessel pathological changes of the endplate and degeneration of the intervertebral disc in diabetic rats
por: Chen, Sen, et al.
Publicado: (2020)

Does Vertebral Endplate Morphology Influence Outcomes in Lumbar Total Disc Arthroplasty? Part II: Clinical and Radiographic Results as Evaluated Utilizing the Vertebral Endplate Yue-Bertagnoli (VEYBR) Classification
por: Oetgen, Matthew E., et al.
Publicado: (2008)

Are the determinants of vertebral endplate changes and severe disc degeneration in the lumbar spine the same? A magnetic resonance imaging study in middle-aged male workers
por: Kuisma, Mari, et al.
Publicado: (2008)

Novel Biomarkers of Health and Degeneration in Human Intervertebral Discs: In-depth Proteomic Analysis of Collagen Framework of Fetal, Healthy, Scoliotic, Degenerate, and Herniated Discs
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2023)

Inhibition of both endplate nutritional pathways results in intervertebral disc degeneration in a goat model
por: Yin, Si, et al.
Publicado: (2019)

A systematic morphology study on the effect of high glucose on intervertebral disc endplate degeneration in mice
por: Quan, Huilin, et al.
Publicado: (2023)

Does Vertebral Endplate Morphology Influence Outcomes in Lumbar Disc Arthroplasty? Part I: An Initial Assessment of a Novel Classification System of Lumbar Endplate Morphology
por: Yue, James J., et al.
Publicado: (2008)

Relationship between Endplate Defects, Modic Change, Disc Degeneration, and Facet Joint Degeneration in Patients with Low Back Pain
por: Lv, Bin, et al.
Publicado: (2019)

Quantitative Predictive Imaging Biomarkers of Lumbar Intervertebral Disc Degeneration
por: Vadapalli, Rammohan, et al.
Publicado: (2019)

Endplates Changes Related to Age and Vertebral Segment
por: Herrero, Carlos Fernando P. S., et al.
Publicado: (2014)

Structure‐function relationships of the human vertebral endplate
por: Wu, Yuanqiao, et al.
Publicado: (2021)

Effects of endplate healing morphology on intervertebral disc degeneration after pedicle screw fixation for thoracolumbar fractures
por: Su, Yunshan, et al.
Publicado: (2021)

Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9
por: Jiang, Chao, et al.
Publicado: (2019)

Effect of cartilaginous endplates on extruded disc resorption in lumbar disc herniation
por: Kawaguchi, Kenichi, et al.
Publicado: (2018)

Proton Density Fat Fraction Spine MRI for Differentiation of Erosive Vertebral Endplate Degeneration and Infectious Spondylitis
por: Schmeel, Frederic Carsten, et al.
Publicado: (2021)

Modic type 2 changes are fibroinflammatory changes with complement system involvement adjacent to degenerated vertebral endplates
por: Heggli, Irina, et al.
Publicado: (2022)

Amygdalin Delays Cartilage Endplate Degeneration and Improves Intervertebral Disc Degeneration by Inhibiting NF-κB Signaling Pathway and Inflammatory Response
por: Zeng, Qinghe, et al.
Publicado: (2023)

Species variation in the cartilaginous endplate of the lumbar intervertebral disc
por: Li, Yun‐He, et al.
Publicado: (2022)

How is spinal range of motion affected by disc- and facet degeneration and spinopelvic anatomy?
por: Farshad, Mazda, et al.
Publicado: (2021)

Geometry of the Intervertebral Volume and Vertebral Endplates of the Human Spine
por: van der Houwen, E. B., et al.
Publicado: (2009)

Endplate and intervertebral disc injuries in acute and single level osteoporotic vertebral fractures: is there any association with the process of bone healing?
por: Fujiwara, Tatsuhiko, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_prfnfi8f1338tgn34kjgt40054