Loss of TSC1/TSC2 sensitizes immune checkpoint blockade in non–small cell lung cancer

Tuberous sclerosis complex subunit 1 (TSC1) and 2 (TSC2) are frequently mutated in non–small cell lung cancer (NSCLC), however, their effects on antitumor immunity remained unexplored. A CRISPR screening in murine Kras(G12D)/Trp53(−/−) (KP) model identified Tsc1 and Tsc2 as potent regulators of prog...

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Detalles Bibliográficos
Autores principales: Huang, Qingyuan, Li, Fei, Hu, Hai, Fang, Zhaoyuan, Gao, Zhendong, Xia, Guozhan, Ng, Wai-Lung, Khodadadi-Jamayran, Alireza, Chen, Ting, Deng, Jiehui, Zhang, Hua, Almonte, Christina, Labbe, Kristen, Han, Han, Geng, Ke, Tang, Sittinon, Freeman, Gordon J., Li, Yuan, Chen, Haiquan, Wong, Kwok-Kin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816329/
https://www.ncbi.nlm.nih.gov/pubmed/35119931
http://dx.doi.org/10.1126/sciadv.abi9533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816329/
https://www.ncbi.nlm.nih.gov/pubmed/35119931
http://dx.doi.org/10.1126/sciadv.abi9533

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