The CDK1-TOPBP1-PLK1 axis regulates the Bloom’s syndrome helicase BLM to suppress crossover recombination in somatic cells

Bloom’s syndrome is caused by inactivation of the BLM helicase, which functions with TOP3A and RMI1-2 (BTR complex) to dissolve recombination intermediates and avoid somatic crossing-over. We show here that crossover avoidance by BTR further requires the activity of cyclin-dependent kinase-1 (CDK1),...

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Detalles Bibliográficos
Autores principales: Balbo Pogliano, Chiara, Ceppi, Ilaria, Giovannini, Sara, Petroulaki, Vasiliki, Palmer, Nathan, Uliana, Federico, Gatti, Marco, Kasaciunaite, Kristina, Freire, Raimundo, Seidel, Ralf, Altmeyer, Matthias, Cejka, Petr, Matos, Joao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816346/
https://www.ncbi.nlm.nih.gov/pubmed/35119917
http://dx.doi.org/10.1126/sciadv.abk0221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816346/
https://www.ncbi.nlm.nih.gov/pubmed/35119917
http://dx.doi.org/10.1126/sciadv.abk0221

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