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Closer Look at Inverse Electron Demand Diels–Alder and Nucleophilic Addition Reactions on s-Tetrazines Using Enhanced Sampling Methods

Inverse electron demand [4+2] Diels–Alder (iEDDA) reactions as well as unprecedented nucleophilic (azaphilic) additions of R-substituted silyl-enol ethers (where R is Phenyl, Methyl, and Hydrogen) to 1,2,4,5-tetrazine (s-tetrazine) catalyzed by [Formula: see text] have recently been discovered (Simo...

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Detalles Bibliográficos
Autores principales: Ketkaew, Rangsiman, Creazzo, Fabrizio, Luber, Sandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816378/
https://www.ncbi.nlm.nih.gov/pubmed/35153451
http://dx.doi.org/10.1007/s11244-021-01516-y