Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma(-/-) mouse studies having informed our understanding of GZMA’s physiological function. We show herein that Gzma(-/-) mice have a mixed C57BL/6J and C57BL/6N genetic background and retain the full-length nicotinamide...

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Detalles Bibliográficos
Autores principales: Rawle, Daniel J, Le, Thuy T, Dumenil, Troy, Bishop, Cameron, Yan, Kexin, Nakayama, Eri, Bird, Phillip I, Suhrbier, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816380/
https://www.ncbi.nlm.nih.gov/pubmed/35119362
http://dx.doi.org/10.7554/eLife.70207

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816380/
https://www.ncbi.nlm.nih.gov/pubmed/35119362
http://dx.doi.org/10.7554/eLife.70207

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