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Widespread discrepancy in Nnt genotypes and genetic backgrounds complicates granzyme A and other knockout mouse studies

Granzyme A (GZMA) is a serine protease secreted by cytotoxic lymphocytes, with Gzma(-/-) mouse studies having informed our understanding of GZMA’s physiological function. We show herein that Gzma(-/-) mice have a mixed C57BL/6J and C57BL/6N genetic background and retain the full-length nicotinamide...

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Detalles Bibliográficos
Autores principales:	Rawle, Daniel J, Le, Thuy T, Dumenil, Troy, Bishop, Cameron, Yan, Kexin, Nakayama, Eri, Bird, Phillip I, Suhrbier, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Immunology and Inflammation
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816380/ https://www.ncbi.nlm.nih.gov/pubmed/35119362 http://dx.doi.org/10.7554/eLife.70207

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