Solid Dispersions of Gefitinib Prepared by Spray Drying with Improved Mucoadhesive and Drug Dissolution Properties

Gefitinib is a tyrosine kinase inhibitor that is intended for oral administration yet suffers poor bioavailability along with undesirable side effects. To enhance its solubility and allow colon targeting, gefitinib (ZD) and blends of different ratios of polymers (ternary dispersion) were prepared in...

Descripción completa

Detalles Bibliográficos
Autores principales: Mustafa, Wesam W., Fletcher, John, Khoder, Mouhamad, Alany, Raid G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816420/
https://www.ncbi.nlm.nih.gov/pubmed/34984564
http://dx.doi.org/10.1208/s12249-021-02187-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816420/
https://www.ncbi.nlm.nih.gov/pubmed/34984564
http://dx.doi.org/10.1208/s12249-021-02187-4

Ejemplares similares