PBPK Simulation-Based Evaluation of Ganciclovir Crystalluria Risk Factors: Effect of Renal Impairment, Old Age, and Low Fluid Intake

Dosing guidance is often lacking for chronic kidney disease (CKD) due to exclusion of such patients from pivotal clinical trials. Physiologically based pharmacokinetic (PBPK) modelling supports model-informed dosing when clinical data are lacking, but application of these approaches to patients with...

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Detalles Bibliográficos
Autores principales: Scotcher, Daniel, Galetin, Aleksandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816528/
https://www.ncbi.nlm.nih.gov/pubmed/34907479
http://dx.doi.org/10.1208/s12248-021-00654-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816528/
https://www.ncbi.nlm.nih.gov/pubmed/34907479
http://dx.doi.org/10.1208/s12248-021-00654-1

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