ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper

Aldehyde dehydrogenase 1A1 (ALDH) is a cancer stem cell marker highly expressed in metastatic cells. Disulfiram (Dis) is an FDA-approved antialcoholism drug that inhibits ALDH and has been studied as a candidate for drug repurposing in multiple neoplasia. Dis cytotoxicity in cancer cells has been sh...

Descripción completa

Detalles Bibliográficos
Autores principales: Mandell, Jonathan B., Douglas, Nerone, Ukani, Vrutika, Beumer, Jan H., Guo, Jianxia, Payne, John, Newman, Rebecca, Mancinelli, Luigi, Intini, Giuseppe, Anderson, Carolyn J., Watters, Rebecca, Weiss, Kurt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816591/
https://www.ncbi.nlm.nih.gov/pubmed/35125923
http://dx.doi.org/10.1155/2022/7157507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816591/
https://www.ncbi.nlm.nih.gov/pubmed/35125923
http://dx.doi.org/10.1155/2022/7157507

Ejemplares similares