Cargando…

ALDH1A1 Gene Expression and Cellular Copper Levels between Low and Highly Metastatic Osteosarcoma Provide a Case for Novel Repurposing with Disulfiram and Copper

Aldehyde dehydrogenase 1A1 (ALDH) is a cancer stem cell marker highly expressed in metastatic cells. Disulfiram (Dis) is an FDA-approved antialcoholism drug that inhibits ALDH and has been studied as a candidate for drug repurposing in multiple neoplasia. Dis cytotoxicity in cancer cells has been sh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mandell, Jonathan B., Douglas, Nerone, Ukani, Vrutika, Beumer, Jan H., Guo, Jianxia, Payne, John, Newman, Rebecca, Mancinelli, Luigi, Intini, Giuseppe, Anderson, Carolyn J., Watters, Rebecca, Weiss, Kurt
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816591/ https://www.ncbi.nlm.nih.gov/pubmed/35125923 http://dx.doi.org/10.1155/2022/7157507

Ejemplares similares

Combination Therapy with Disulfiram, Copper, and Doxorubicin for Osteosarcoma: In Vitro Support for a Novel Drug Repurposing Strategy
por: Mandell, Jonathan B., et al.
Publicado: (2019)

Recent Advances in Repurposing Disulfiram and Disulfiram Derivatives as Copper-Dependent Anticancer Agents
por: Kannappan, Vinodh, et al.
Publicado: (2021)

The Effect of Disulfiram and Copper on Cellular Viability, ER Stress and ALDH Expression of Human Meningioma Cells
por: Kao, Ying, et al.
Publicado: (2022)

Targeting ALDH1A1 by disulfiram/copper complex inhibits non-small cell lung cancer recurrence driven by ALDH-positive cancer stem cells
por: Liu, Xinwei, et al.
Publicado: (2016)

Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
por: Liu, P, et al.
Publicado: (2012)

Disulfiram reduces metastatic osteosarcoma tumor burden in an immunocompetent Balb/c or-thotopic mouse model
por: Crasto, Jared Anthony, et al.
Publicado: (2018)

Comment on ‘Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells'
por: Cvek, B
Publicado: (2013)

Reply: Cytotoxic effect of disulfiram/copper on human glioblastoma cell lines and ALDH-positive cancer-stem-like cells
por: Liu, P, et al.
Publicado: (2013)

Novel Disulfiram Derivatives as ALDH1a1-Selective Inhibitors
por: Omran, Ziad
Publicado: (2022)

The cytotoxic mechanisms of disulfiram and copper(ii) in cancer cells
por: Tawari, Patricia Erebi, et al.
Publicado: (2015)

Cell cycle specific radiosensitisation by the disulfiram and copper complex
por: Tesson, Mathias, et al.
Publicado: (2017)

Disulfiram repurposing combined with nutritional copper supplement as add-on to chemotherapy in recurrent glioblastoma (DIRECT): Study protocol for a randomized controlled trial
por: Jakola, Asgeir Store, et al.
Publicado: (2018)

Differential Cytotoxicity Mechanisms of Copper Complexed with Disulfiram in Oral Cancer Cells
por: Chen, Ssu-Yu, et al.
Publicado: (2021)

Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems
por: Kang, Xuejia, et al.
Publicado: (2023)

The Disulfiram/Copper Complex Induces Autophagic Cell Death in Colorectal Cancer by Targeting ULK1
por: Hu, Yeting, et al.
Publicado: (2021)

Repurposing Disulfiram as an Antifungal Agent: Development of a New Disulfiram Vaginal Mucoadhesive Gel
por: Lajarin-Reinares, Maria, et al.
Publicado: (2023)

Avenues of research in dietary interventions to target tumor metabolism in osteosarcoma
por: Leite, Taiana Campos, et al.
Publicado: (2021)

Disulfiram in glioma: Literature review of drug repurposing
por: Zhong, Shiyu, et al.
Publicado: (2022)

Repurposing Disulfiram as an Antimicrobial Agent in Topical Infections
por: Lajarin-Reinares, Maria, et al.
Publicado: (2022)

Targeting cancer stem cells by disulfiram and copper sensitizes radioresistant chondrosarcoma to radiation
por: Wang, Kun, et al.
Publicado: (2021)

Disulfiram/Copper Suppresses Cancer Stem Cell Activity in Differentiated Thyroid Cancer Cells by Inhibiting BMI1 Expression
por: Ni, Yung-Lun, et al.
Publicado: (2022)

Repurposing Disulfiram for Targeting of Glioblastoma Stem Cells: An In Vitro Study
por: Zirjacks, Lisa, et al.
Publicado: (2021)

Improving the Therapeutic Efficacy of Sorafenib for Hepatocellular Carcinoma by Repurposing Disulfiram
por: Zhang, Gong, et al.
Publicado: (2022)

Diethyldithiocarbamate-copper nanocomplex reinforces disulfiram chemotherapeutic efficacy through light-triggered nuclear targeting
por: Ren, Liting, et al.
Publicado: (2020)

Disulfiram‐copper activates chloride currents and induces apoptosis with tyrosine kinase in prostate cancer cells
por: Lei, Wei, et al.
Publicado: (2021)

Disulfiram/Copper Induces Immunogenic Cell Death and Enhances CD47 Blockade in Hepatocellular Carcinoma
por: Gao, Xingxing, et al.
Publicado: (2022)

Disulfiram Transcends ALDH Inhibitory Activity When Targeting Ovarian Cancer Tumor-Initiating Cells
por: Caminear, Michael W., et al.
Publicado: (2022)

Drug Repurposing of the Alcohol Abuse Medication Disulfiram as an Anti-Parasitic Agent
por: Shirley, Debbie-Ann, et al.
Publicado: (2021)

Upregulation of ALDH1B1 promotes tumor progression in osteosarcoma
por: Wang, Xin, et al.
Publicado: (2017)

Disulfiram/Copper induces antitumor activity against gastric cancer via the ROS/MAPK and NPL4 pathways
por: Liu, Yao, et al.
Publicado: (2022)

Disulfiram suppressed ethanol promoted RANKL-induced osteoclastogenesis in vitro and ethanol-induced osteoporosis in vivo via ALDH1A1-NFATc1 axis
por: Jia, Yewei, et al.
Publicado: (2019)

Disulfiram Chelated With Copper Inhibits the Growth of Gastric Cancer Cells by Modulating Stress Response and Wnt/β-catenin Signaling
por: Wang, Ling, et al.
Publicado: (2020)

Disulfiram and copper combination therapy targets NPL4, cancer stem cells and extends survival in a medulloblastoma model
por: Serra, Riccardo, et al.
Publicado: (2021)

Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis
por: Ren, Xueying, et al.
Publicado: (2021)

Using Ligand-Accelerated Catalysis to Repurpose Fluorogenic Reactions for Platinum or Copper
por: Pham, Dianne, et al.
Publicado: (2020)

A Phase 1 dose-escalation study of disulfiram and copper gluconate in patients with advanced solid tumors involving the liver using S-glutathionylation as a biomarker
por: Kelley, Kristen C., et al.
Publicado: (2021)

Disulfiram anti-cancer efficacy without copper overload is enhanced by extracellular H(2)O(2) generation: antagonism by tetrathiomolybdate
por: Calderon-Aparicio, Ali, et al.
Publicado: (2015)

A Ferritin–Albumin–Cu Nanoparticle that Efficaciously Delivers Copper(II) Ions to a Tumor and Improves the Therapeutic Efficacy of Disulfiram
por: Xu, Nuo, et al.
Publicado: (2020)

Cytotoxic effect of disulfiram/copper on human cervical cancer cell lines and LGR5-positive cancer stem-like cells
por: Cao, Hao-Zhe, et al.
Publicado: (2022)

Effect of Disulfiram and Copper Plus Chemotherapy vs Chemotherapy Alone on Survival in Patients With Recurrent Glioblastoma: A Randomized Clinical Trial
por: Werlenius, Katja, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ce5skj6a3jn12dn913mpnc6a22