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Performance Evaluation of Montelukast Pediatric Formulations: Part II — a PBPK Modelling Approach
This study aimed to build a physiologically based pharmacokinetic (PBPK) model coupled with age-appropriate in vitro dissolution data to describe drug performance in adults and pediatric patients. Montelukast sodium was chosen as a model drug. Two case studies were investigated: case study 1 focused...
Autores principales: | Guimarães, Mariana, Vertzoni, Maria, Fotaki, Nikoletta |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816611/ https://www.ncbi.nlm.nih.gov/pubmed/35013803 http://dx.doi.org/10.1208/s12248-021-00662-1 |
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