Multidimensional Dynamics of the Proteome in the Neurodegenerative and Aging Mammalian Brain

The amount of any given protein in the brain is determined by the rates of its synthesis and destruction, which are regulated by different cellular mechanisms. Here, we combine metabolic labeling in live mice with global proteomic profiling to simultaneously quantify both the flux and amount of prot...

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Detalles Bibliográficos
Autores principales: Andrews, Byron, Murphy, Alan E., Stofella, Michele, Maslen, Sarah, Almeida-Souza, Leonardo, Skehel, J. Mark, Skene, Nathan G., Sobott, Frank, Frank, René A.W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816717/
https://www.ncbi.nlm.nih.gov/pubmed/34979241
http://dx.doi.org/10.1016/j.mcpro.2021.100192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816717/
https://www.ncbi.nlm.nih.gov/pubmed/34979241
http://dx.doi.org/10.1016/j.mcpro.2021.100192

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