Cargando…

SMAD4 mutations do not preclude epithelial–mesenchymal transition in colorectal cancer

Transforming growth factor beta (TGFβ) superfamily signaling is a prime inducer of epithelial-mesenchymal transitions (EMT) that foster cancer cell invasion and metastasis, a major cause of cancer-related deaths. Yet, TGFβ signaling is frequently inactivated in human tumor entities including colorec...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frey, Patrick, Devisme, Antoine, Rose, Katja, Schrempp, Monika, Freihen, Vivien, Andrieux, Geoffroy, Boerries, Melanie, Hecht, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816731/ https://www.ncbi.nlm.nih.gov/pubmed/34857888 http://dx.doi.org/10.1038/s41388-021-02128-2

Ejemplares similares

Canonical BMP Signaling Executes Epithelial-Mesenchymal Transition Downstream of SNAIL1
por: Frey, Patrick, et al.
Publicado: (2020)

SNAIL1-mediated downregulation of FOXA proteins facilitates the inactivation of transcriptional enhancer elements at key epithelial genes in colorectal cancer cells
por: Jägle, Sabine, et al.
Publicado: (2017)

Loss of the nuclear Wnt pathway effector TCF7L2 promotes migration and invasion of human colorectal cancer cells
por: Wenzel, Janna, et al.
Publicado: (2020)

Cardiac Regeneration and Tumor Growth—What Do They Have in Common?
por: Dicks, Severin, et al.
Publicado: (2020)

Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1- and Zeb1-independent partial EMT
por: Flum, Marion, et al.
Publicado: (2022)

Alteration of Proteotranscriptomic Landscape Reveals the Transcriptional Regulatory Circuits Controlling Key-Signaling Pathways and Metabolic Reprogramming During Tumor Evolution
por: Andrieux, Geoffroy, et al.
Publicado: (2020)

TGFβ1-Induced EMT in the MCF10A Mammary Epithelial Cell Line Model Is Executed Independently of SNAIL1 and ZEB1 but Relies on JUNB-Coordinated Transcriptional Regulation
por: Antón-García, Pablo, et al.
Publicado: (2023)

BRAF(V600E) drives dedifferentiation in small intestinal and colonic organoids and cooperates with mutant p53 and Apc loss in transformation
por: Reischmann, Nadine, et al.
Publicado: (2020)

Early PSA Change after [(177)Lu]PSMA-617 Radioligand Therapy as a Predicator of Biochemical Response and Overall Survival
por: Kind, Felix, et al.
Publicado: (2021)

Probabilistic reinforcement precludes transitive inference: A preliminary study
por: Camarena, Héctor O., et al.
Publicado: (2023)

Resveratrol Suppresses Epithelial-Mesenchymal Transition in GBM by Regulating Smad-Dependent Signaling
por: Song, Yang, et al.
Publicado: (2019)

Precluding rare outcomes by predicting their absence
por: Schoon, Eric W., et al.
Publicado: (2019)

Thalidomide Inhibits TGF-β1-induced Epithelial to Mesenchymal Transition in Alveolar Epithelial Cells via Smad-Dependent and Smad-Independent Signaling Pathways
por: Zhou, Xian-Long, et al.
Publicado: (2017)

How the Lack of Chitosan Characterization Precludes Implementation of the Safe-by-Design Concept
por: Marques, Cíntia, et al.
Publicado: (2020)

Role of Smad3 signaling in the epithelial-mesenchymal transition of the lens epithelium following injury
por: Meng, Fanlan, et al.
Publicado: (2018)

T-CAST: An optimized CAST-Seq pipeline for TALEN confirms superior safety and efficacy of obligate-heterodimeric scaffolds
por: Rhiel, Manuel, et al.
Publicado: (2023)

Epithelial-mesenchymal transition in primary human bronchial epithelial cells is Smad-dependent and enhanced by fibronectin and TNF-α
por: Câmara, Joana, et al.
Publicado: (2010)

Practical problems may preclude realization of this proposal
por: Della Mea, Vincenzo
Publicado: (2000)

Unilateral Diaphragmatic Agenesis Precluding Laparoscopic Cholecystectomy
por: Wakai, Abel, et al.
Publicado: (2000)

Explaining Underrepresentation: A Theory of Precluded Interest
por: Cheryan, Sapna, et al.
Publicado: (2010)

Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/β-catenin target gene expression
por: Wallmen, Britta, et al.
Publicado: (2012)

CDCA7 promotes TGF‐β‐induced epithelial–mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC
por: Li, Hongyi, et al.
Publicado: (2022)

Repression of Smad3 by silencing Robo1 attenuates epithelial-mesenchymal transition in tracheobronchial stenosis
por: He, Chunyan, et al.
Publicado: (2023)

Lesions in the legs do not preclude ultra-marathon running for 100 days without pain: case report
por: Rutkauskas, Saulius, et al.
Publicado: (2019)

Do Failure of Posterior Tibial Nerve Stimulation Precludes to Use Sacral Neuromodulation in Patient With Overactive Bladder?
por: Berthelot, Louis-Paul, et al.
Publicado: (2019)

The neglected sun: why the sun precludes climate catastrophe
por: Vahrenholt, Fritz, et al.
Publicado: (2012)

Atrio‐Hisian block precludes preexcitation—What is the mechanism?
por: Prabhu, Mukund Aravind, et al.
Publicado: (2018)

The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions
por: Nissanka, Nadee, et al.
Publicado: (2018)

Loss of N-Myc interactor promotes epithelial-mesenchymal-transition by activation of TGF-β/SMAD signaling
por: Devine, Daniel J., et al.
Publicado: (2013)

Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
por: Park, Sujin, et al.
Publicado: (2018)

Identification of Epithelial-Mesenchymal Transition-related Target Genes Induced by the Mutation of Smad3 Linker Phosphorylation
por: Park, Sujin, et al.
Publicado: (2018)

circSMAD2 inhibits the epithelial–mesenchymal transition by targeting miR-629 in hepatocellular carcinoma
por: Zhang, Xianwei, et al.
Publicado: (2018)

Lyn regulates epithelial–mesenchymal transition in CS-exposed model through Smad2/3 signaling
por: Liang, Xiaobo, et al.
Publicado: (2019)

RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC
por: Wang, Xiao-Yan, et al.
Publicado: (2017)

Silencing Smad4 attenuates sensitivity of colorectal cancer cells to cetuximab by promoting epithelial-mesenchymal transition
por: Lin, Zhenlv, et al.
Publicado: (2019)

Cell-Based Models of ‘Cytokine Release Syndrome’ Endorse CD40L and Granulocyte–Macrophage Colony-Stimulating Factor Knockout in Chimeric Antigen Receptor T Cells as Mitigation Strategy
por: Dibas, Ala, et al.
Publicado: (2023)

Gremlin Activates the Smad Pathway Linked to Epithelial Mesenchymal Transdifferentiation in Cultured Tubular Epithelial Cells
por: Rodrigues-Diez, Raquel, et al.
Publicado: (2014)

TIM-3 Participates in the Invasion and Metastasis of Nasopharyngeal Carcinoma via SMAD7/SMAD2/SNAIL1 Axis-Mediated Epithelial-Mesenchymal Transition
por: Xiao, Yangyang, et al.
Publicado: (2020)

The tales of two neighbours: when cholecystitis does not preclude pancreatitis
por: Yahng, Jeong-moh John, et al.
Publicado: (2019)

Inpatient interventions that may preclude outpatient open pyeloplasty in infants
por: Dönmez, M. İrfan, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_lp7tktdqnvh9dflh2q03oqrjtk