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PERK, Beyond an Unfolded Protein Response Sensor in Estrogen-Induced Apoptosis in Endocrine-Resistant Breast Cancer
The discovery of 17β-estradiol (E(2))–induced apoptosis has clinical relevance. Mechanistically, E(2) over activates nuclear estrogen receptor α that results in stress responses. The unfolded protein response (UPR) is initiated by E(2) in the endoplasmic reticulum after hours of treatment in endocri...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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American Association for Cancer Research
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8816868/ https://www.ncbi.nlm.nih.gov/pubmed/34728551 http://dx.doi.org/10.1158/1541-7786.MCR-21-0702 |