ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

Rho family mechano-signaling through the actin cytoskeleton positively regulates physiological TEAD/YAP transcription, while the evolutionarily conserved Hippo tumor suppressor pathway antagonizes this transcription through YAP cytoplasmic localization/degradation. The mechanisms responsible for onc...

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Detalles Bibliográficos
Autores principales: Esposito, Davide, Pant, Ila, Shen, Yao, Qiao, Rui F., Yang, Xiaobao, Bai, Yiyang, Jin, Jian, Poulikakos, Poulikos I., Aaronson, Stuart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817028/
https://www.ncbi.nlm.nih.gov/pubmed/35121738
http://dx.doi.org/10.1038/s41467-022-28319-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817028/
https://www.ncbi.nlm.nih.gov/pubmed/35121738
http://dx.doi.org/10.1038/s41467-022-28319-3

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