Cargando…

ROCK1 mechano-signaling dependency of human malignancies driven by TEAD/YAP activation

Rho family mechano-signaling through the actin cytoskeleton positively regulates physiological TEAD/YAP transcription, while the evolutionarily conserved Hippo tumor suppressor pathway antagonizes this transcription through YAP cytoplasmic localization/degradation. The mechanisms responsible for onc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Esposito, Davide, Pant, Ila, Shen, Yao, Qiao, Rui F., Yang, Xiaobao, Bai, Yiyang, Jin, Jian, Poulikakos, Poulikos I., Aaronson, Stuart A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817028/ https://www.ncbi.nlm.nih.gov/pubmed/35121738 http://dx.doi.org/10.1038/s41467-022-28319-3

Ejemplares similares

Gatekeepers of pancreas: TEAD and YAP
por: Rodríguez-Seguí, Santiago A., et al.
Publicado: (2015)

Repurposing of Drugs Targeting YAP-TEAD Functions
por: Elisi, Gian Marco, et al.
Publicado: (2018)

Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ–TEAD Biosensors
por: Nouri, Kazem, et al.
Publicado: (2019)

Toward the Discovery of a Novel Class of YAP–TEAD Interaction Inhibitors by Virtual Screening Approach Targeting YAP–TEAD Protein–Protein Interface
por: Gibault, Floriane, et al.
Publicado: (2018)

Multifaceted function of YAP/TEAD on chromatin:prospects of ‘A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer’
por: Chen, Lizhen, et al.
Publicado: (2019)

Inhibition of YAP/TAZ-driven TEAD activity prevents growth of NF2-null schwannoma and meningioma
por: Laraba, Liyam, et al.
Publicado: (2022)

Crystal structure of TAZ-TEAD complex reveals a distinct interaction mode from that of YAP-TEAD complex
por: Kaan, Hung Yi Kristal, et al.
Publicado: (2017)

A combat with the YAP/TAZ-TEAD oncoproteins for cancer therapy
por: Pobbati, Ajaybabu V., et al.
Publicado: (2020)

The role of mechano-regulated YAP/TAZ in erectile dysfunction
por: Ji, Mintao, et al.
Publicado: (2023)

TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
por: Cebola, Inês, et al.
Publicado: (2015)

Retinal Degeneration Triggers the Activation of YAP/TEAD in Reactive Müller Cells
por: Hamon, Annaïg, et al.
Publicado: (2017)

FLNC Expression Level Influences the Activity of TEAD-YAP/TAZ Signaling
por: Knyazeva, Anastasia, et al.
Publicado: (2020)

Protein-Protein Interaction Disruptors of the YAP/TAZ-TEAD Transcriptional Complex
por: Pobbati, Ajaybabu V., et al.
Publicado: (2020)

Study of the TEAD‐binding domain of the YAP protein from animal species
por: Mesrouze, Yannick, et al.
Publicado: (2020)

The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
por: Cunningham, Richard, et al.
Publicado: (2022)

Wnt and Src signals converge on YAP‐TEAD to drive intestinal regeneration
por: Guillermin, Oriane, et al.
Publicado: (2021)

Covalent disruptor of YAP-TEAD association suppresses defective Hippo signaling
por: Fan, Mengyang, et al.
Publicado: (2022)

TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
por: Elster, Dana, et al.
Publicado: (2018)

Transformation of normal cells by aberrant activation of YAP via cMyc with TEAD
por: Nishimoto, Masazumi, et al.
Publicado: (2019)

Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD
por: Mesrouze, Yannick, et al.
Publicado: (2017)

Pharmacological blockade of TEAD–YAP reveals its therapeutic limitation in cancer cells
por: Sun, Yang, et al.
Publicado: (2022)

SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors
por: Ahmed, Tamer A., et al.
Publicado: (2019)

Angiomotin stabilization by tankyrase inhibitors antagonizes constitutive TEAD-dependent transcription and proliferation of human tumor cells with Hippo pathway core component mutations
por: Troilo, Albino, et al.
Publicado: (2016)

YAP1 Exerts Its Transcriptional Control via TEAD-Mediated Activation of Enhancers
por: Stein, Claudia, et al.
Publicado: (2015)

YAP/TEAD Co-Activator Regulated Pluripotency and Chemoresistance in Ovarian Cancer Initiated Cells
por: Xia, Yan, et al.
Publicado: (2014)

Dropwort-induced metabolic reprogramming restrains YAP/TAZ/TEAD oncogenic axis in mesothelioma
por: Pulito, Claudio, et al.
Publicado: (2019)

Homeobox A4 suppresses vascular remodeling by repressing YAP/TEAD transcriptional activity
por: Kimura, Masahiro, et al.
Publicado: (2020)

YAP‐TEAD up‐regulates IRS2 expression to induce and deteriorate oesophageal cancer
por: Xu, Xiangming, et al.
Publicado: (2021)

Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects
por: Pearson, Joel D., et al.
Publicado: (2021)

The Telluride YAP/TAZ and TEAD Workshop: A Small Meeting with a Big Impact
por: Weinberg, Guy L., et al.
Publicado: (2023)

YAP/TEAD-induced PRIM1 contributes to the progression and poor prognosis of gastric carcinoma
por: Guo, Zijun, et al.
Publicado: (2023)

A covalent inhibitor of the YAP–TEAD transcriptional complex identified by high-throughput screening
por: Nutsch, Kayla, et al.
Publicado: (2023)

YAP/TAZ Related BioMechano Signal Transduction and Cancer Metastasis
por: Martinez, Bridget, et al.
Publicado: (2019)

Verteporfin, a suppressor of YAP–TEAD complex, presents promising antitumor properties on ovarian cancer
por: Feng, Juntao, et al.
Publicado: (2016)

NUP37, a positive regulator of YAP/TEAD signaling, promotes the progression of hepatocellular carcinoma
por: Luo, Xiaoling, et al.
Publicado: (2017)

Author Correction: TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
por: Elster, Dana, et al.
Publicado: (2018)

A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
por: Qi, Yangfan, et al.
Publicado: (2016)

Analysis in silico of the functional interaction between WNT5A and YAP/TEAD signaling in cancer
por: Astudillo, Pablo
Publicado: (2021)

YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes
por: Gao, Yunan, et al.
Publicado: (2021)

CK2-induced cooperation of HHEX with the YAP-TEAD4 complex promotes colorectal tumorigenesis
por: Guo, Yuegui, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4sm2io007o2v6ov21flk1jtmti