Cargando…

Placental genomics mediates genetic associations with complex health traits and disease

As the master regulator in utero, the placenta is core to the Developmental Origins of Health and Disease (DOHaD) hypothesis but is historically understudied. To identify placental gene-trait associations (GTAs) across the life course, we perform distal mediator-enriched transcriptome-wide associati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bhattacharya, Arjun, Freedman, Anastasia N., Avula, Vennela, Harris, Rebeca, Liu, Weifang, Pan, Calvin, Lusis, Aldons J., Joseph, Robert M., Smeester, Lisa, Hartwell, Hadley J., Kuban, Karl C. K., Marsit, Carmen J., Li, Yun, O’Shea, T. Michael, Fry, Rebecca C., Santos, Hudson P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817049/ https://www.ncbi.nlm.nih.gov/pubmed/35121757 http://dx.doi.org/10.1038/s41467-022-28365-x

Ejemplares similares

Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm
por: Santos Jr, Hudson P., et al.
Publicado: (2020)

Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm
por: Bangma, Jacqueline T., et al.
Publicado: (2020)

Differential Placental CpG Methylation is Associated with Chronic Lung Disease of Prematurity
por: Jackson, Wesley M., et al.
Publicado: (2022)

Placental CpG methylation of infants born extremely preterm predicts cognitive impairment later in life
por: Tilley, Sloane K., et al.
Publicado: (2018)

Placental CpG Methylation of Inflammation, Angiogenic, and Neurotrophic Genes and Retinopathy of Prematurity
por: Bulka, Catherine M., et al.
Publicado: (2019)

CpG Methylation Patterns in Placenta and Neonatal Blood are Differentially Associated with Neonatal Inflammation
por: Eaves, Lauren A., et al.
Publicado: (2023)

Placental transcriptional signatures associated with cerebral white matter damage in the neonate
por: Marable, Carmen Amelia, et al.
Publicado: (2022)

Prenatal Metal Exposure Alters the Placental Proteome in a Sex-Dependent Manner in Extremely Low Gestational Age Newborns: Links to Gestational Age
por: Freedman, Anastasia N., et al.
Publicado: (2023)

Placental microRNAs: Responders to environmental chemicals and mediators of pathophysiology of the human placenta
por: Addo, Kezia A., et al.
Publicado: (2020)

Innovative computational approaches shed light on genetic mechanisms underlying cognitive impairment among children born extremely preterm
por: Liu, Weifang, et al.
Publicado: (2022)

Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn (ELGAN) cohort
por: Addo, Kezia A, et al.
Publicado: (2019)

Acetaminophen use during pregnancy and DNA methylation in the placenta of the extremely low gestational age newborn (ELGAN) cohort
por: Addo, Kezia A, et al.
Publicado: (2020)

Microorganisms in the human placenta are associated with altered CpG methylation of immune and inflammation-related genes
por: Tomlinson, Martha Scott, et al.
Publicado: (2017)

Vestigial-like 3 is an inhibitor of adipocyte differentiation
por: Halperin, Daniel S., et al.
Publicado: (2013)

Sexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns
por: Santos, Hudson P., et al.
Publicado: (2023)

Pre-pregnancy BMI-associated miRNA and mRNA expression signatures in the placenta highlight a sexually-dimorphic response to maternal underweight status
por: Clark, Jeliyah, et al.
Publicado: (2021)

Integrating genetic and gene expression data: application to cardiovascular and metabolic traits in mice
por: Drake, Thomas A., et al.
Publicado: (2006)

Coagulation factor with potential for the treatment of heart failure
por: Cao, Yang, et al.
Publicado: (2022)

Using genetic markers to orient the edges in quantitative trait networks: The NEO software
por: Aten, Jason E, et al.
Publicado: (2008)

The Systems Genetics Resource: A Web Application to Mine Global Data for Complex Disease Traits
por: van Nas, Atila, et al.
Publicado: (2013)

Intestinal cell type-specific communication networks underlie homeostasis and response to Western diet
por: Wang, Yu-Chen, et al.
Publicado: (2023)

Sex-based differences in placental DNA methylation profiles related to gestational age: an NIH ECHO meta-analysis
por: Bulka, Catherine M., et al.
Publicado: (2023)

Systems-based approaches for investigation of inter-tissue communication
por: Seldin, Marcus M., et al.
Publicado: (2019)

Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice
por: Ishikawa, Kazunobu, et al.
Publicado: (2012)

Tribute to Dr. Steve Schwartz
por: Lusis, Aldons J., et al.
Publicado: (2020)

Genomic biomarkers of prenatal intrauterine inflammation in umbilical cord tissue predict later life neurological outcomes
por: Tilley, Sloane K., et al.
Publicado: (2017)

Prenatal exposure to multiple metallic and metalloid trace elements and the risk of bacterial sepsis in extremely low gestational age newborns: A prospective cohort study
por: Bulka, Catherine M., et al.
Publicado: (2022)

Neurocognitive and social-communicative function of children born very preterm at 10 years of age: Associations with microorganisms recovered from the placenta parenchyma
por: Tomlinson, Martha Scott, et al.
Publicado: (2019)

Placental lncRNA expression associated with placental cadmium concentrations and birth weight
por: Hussey, Michael R, et al.
Publicado: (2020)

Roles of Macrophages in Atherogenesis
por: Farahi, Lia, et al.
Publicado: (2021)

Extreme prematurity and attention deficit: epidemiology and prevention
por: O'Shea, T. Michael, et al.
Publicado: (2013)

Systems Genetics Analysis of Mouse Chondrocyte Differentiation
por: Suwanwela, Jaijam, et al.
Publicado: (2011)

Genetic control of the mouse HDL proteome defines HDL traits, function, and heterogeneity
por: Pamir, Nathalie, et al.
Publicado: (2019)

Genetic and Genomic Analysis of a Fat Mass Trait with Complex Inheritance Reveals Marked Sex Specificity
por: Wang, Susanna, et al.
Publicado: (2006)

Multi-omics approaches to disease
por: Hasin, Yehudit, et al.
Publicado: (2017)

Developmental chronodisruption alters placental signaling in mice
por: Clarkson-Townsend, Danielle A., et al.
Publicado: (2021)

Systems genetics approaches for understanding complex traits with relevance for human disease
por: Allayee, Hooman, et al.
Publicado: (2023)

Impact of Individual Traits, Saturated Fat, and Protein Source on the Gut Microbiome
por: Lang, Jennifer M., et al.
Publicado: (2018)

Early life antecedents of positive child health among 10- year-old children born extremely preterm
por: Bangma, Jacqueline T, et al.
Publicado: (2019)

Placental Expression of Imprinted Genes, Overall and in Sex-Specific Patterns, Associated with Placental Cadmium Concentrations and Birth Size
por: Everson, Todd M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_t8t0haofr0p27ptsf4d0a6edeu