In Vitro to In Vivo Extrapolation Linked to Physiologically Based Pharmacokinetic Models for Assessing the Brain Drug Disposition

Drug development for the central nervous system (CNS) is a complex endeavour with low success rates, as the structural complexity of the brain and specifically the blood-brain barrier (BBB) poses tremendous challenges. Several in vitro brain systems have been evaluated, but the ultimate use of these...

Descripción completa

Detalles Bibliográficos
Autores principales: Murata, Yukiko, Neuhoff, Sibylle, Rostami-Hodjegan, Amin, Takita, Hiroyuki, Al-Majdoub, Zubida M., Ogungbenro, Kayode
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817058/
https://www.ncbi.nlm.nih.gov/pubmed/35028763
http://dx.doi.org/10.1208/s12248-021-00675-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817058/
https://www.ncbi.nlm.nih.gov/pubmed/35028763
http://dx.doi.org/10.1208/s12248-021-00675-w

Ejemplares similares