γ‐Secretase modulators show selectivity for γ‐secretase–mediated amyloid precursor protein intramembrane processing

The aggregation of β‐amyloid peptide 42 results in the formation of toxic oligomers and plaques, which plays a pivotal role in Alzheimer's disease pathogenesis. Aβ42 is one of several Aβ peptides, all of Aβ30 to Aβ43 that are produced as a result of γ‐secretase–mediated regulated intramembrane...

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Detalles Bibliográficos
Autores principales: Weber, Tobias A., Lundkvist, Johan, Wanngren, Johanna, Kvartsberg, Hlin, Jin, ShaoBo, Larssen, Pia, Wu, Dan, Oliveira, Daniel V., Minta, Karolina, Brinkmalm, Gunnar, Zetterberg, Henrik, Blennow, Kaj, Nordvall, Gunnar, Winblad, Bengt, Portelius, Erik, Karlström, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817114/
https://www.ncbi.nlm.nih.gov/pubmed/34931449
http://dx.doi.org/10.1111/jcmm.17146

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817114/
https://www.ncbi.nlm.nih.gov/pubmed/34931449
http://dx.doi.org/10.1111/jcmm.17146

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