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AR imposes different effects on ZFHX3 transcription depending on androgen status in prostate cancer cells

Both androgen receptor (AR) and the ZFHX3 transcription factor modulate prostate development. While AR drives prostatic carcinogenesis, ZFHX3 is a tumour suppressor whose loss activates the PI3K/AKT signalling in advanced prostate cancer (PCa). However, it is unknown whether ZFHX3 and AR are functio...

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Detalles Bibliográficos
Autores principales: Fu, Xing, Zhang, Zhiqian, Liu, Mingcheng, Li, Juan, A, Jun, Fu, Liya, Huang, Chenyang, Dong, Jin‐Tang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8817138/
https://www.ncbi.nlm.nih.gov/pubmed/34953044
http://dx.doi.org/10.1111/jcmm.17125