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RB1 loss in castration-resistant prostate cancer confers vulnerability to LSD1 inhibition
Genomic loss of RB1 is a common alteration in castration-resistant prostate cancer (CRPC) and is associated with poor patient outcomes. RB1 loss is also a critical event that promotes the neuroendocrine transdifferentiation of prostate cancer (PCa) induced by the androgen receptor (AR) signaling inh...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818029/ https://www.ncbi.nlm.nih.gov/pubmed/34975152 http://dx.doi.org/10.1038/s41388-021-02135-3 |