RB1 loss in castration-resistant prostate cancer confers vulnerability to LSD1 inhibition

Genomic loss of RB1 is a common alteration in castration-resistant prostate cancer (CRPC) and is associated with poor patient outcomes. RB1 loss is also a critical event that promotes the neuroendocrine transdifferentiation of prostate cancer (PCa) induced by the androgen receptor (AR) signaling inh...

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Detalles Bibliográficos
Autores principales: Han, Wanting, Liu, Mingyu, Han, Dong, Li, Muqing, Toure, Anthia A, Wang, Zifeng, Besschetnova, Anna, Patalano, Susan, Macoska, Jill A., Gao, Shuai, Hansen He, Housheng, Cai, Changmeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818029/
https://www.ncbi.nlm.nih.gov/pubmed/34975152
http://dx.doi.org/10.1038/s41388-021-02135-3

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