TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas

PURPOSE: The epigenetic mechanisms involved in transcriptional regulation leading to malignant phenotype in gliomas remains poorly understood. Topoisomerase IIB (TOP2B), an enzyme that decoils and releases torsional forces in DNA, is overexpressed in a subset of gliomas. Therefore, we investigated i...

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Detalles Bibliográficos
Autores principales: Gonzalez-Buendia, Edgar, Zhao, Junfei, Wang, Lu, Mukherjee, Subhas, Zhang, Daniel, Arrieta, Víctor A., Feldstein, Eric, Kane, J. Robert, Kang, Seong Jae, Lee-Chang, Catalina, Mahajan, Aayushi, Chen, Li, Realubit, Ronald, Karan, Charles, Magnuson, Lisa, Horbinski, Craig, Marshall, Stacy A., Sarkaria, Jann N., Mohyeldin, Ahmed, Nakano, Ichiro, Bansal, Mukesh, James, Charles D., Brat, Daniel J., Ahmed, Atique, Canoll, Peter, Rabadan, Raul, Shilatifard, Ali, Sonabend, Adam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2021
Materias:
Translational Cancer Mechanisms and Therapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818263/
https://www.ncbi.nlm.nih.gov/pubmed/34433651
http://dx.doi.org/10.1158/1078-0432.CCR-21-0312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818263/
https://www.ncbi.nlm.nih.gov/pubmed/34433651
http://dx.doi.org/10.1158/1078-0432.CCR-21-0312

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