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TOP2B Enzymatic Activity on Promoters and Introns Modulates Multiple Oncogenes in Human Gliomas
PURPOSE: The epigenetic mechanisms involved in transcriptional regulation leading to malignant phenotype in gliomas remains poorly understood. Topoisomerase IIB (TOP2B), an enzyme that decoils and releases torsional forces in DNA, is overexpressed in a subset of gliomas. Therefore, we investigated i...
Autores principales: | Gonzalez-Buendia, Edgar, Zhao, Junfei, Wang, Lu, Mukherjee, Subhas, Zhang, Daniel, Arrieta, Víctor A., Feldstein, Eric, Kane, J. Robert, Kang, Seong Jae, Lee-Chang, Catalina, Mahajan, Aayushi, Chen, Li, Realubit, Ronald, Karan, Charles, Magnuson, Lisa, Horbinski, Craig, Marshall, Stacy A., Sarkaria, Jann N., Mohyeldin, Ahmed, Nakano, Ichiro, Bansal, Mukesh, James, Charles D., Brat, Daniel J., Ahmed, Atique, Canoll, Peter, Rabadan, Raul, Shilatifard, Ali, Sonabend, Adam M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for Cancer Research
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8818263/ https://www.ncbi.nlm.nih.gov/pubmed/34433651 http://dx.doi.org/10.1158/1078-0432.CCR-21-0312 |
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